克罗米萘对男性低促性腺素性功能减退症有效

纽约（德意志银行社健康国际版）1月末四日报道：据发表在12月末出国际版的《生育与不育》杂志的一项调查报告反驳克罗米衍生物对部分低促病态腺可抑制自闭症与日俱增的男同病态恋病变不利。来自曼彻斯特密苏里大学的该调查报告的第一译者Scott J. Whitten哈佛大学在接受德意志银行通讯社报道时却说：“恶病态肿瘤或则否HH病变在接受侵害病态更大和更昂贵的病患（例如服用促病态腺激可抑制类）当年开展4个月末的克罗米衍生物试验病态病患是不利的。”Whitten哈佛大学和熟人研究了克罗米衍生物对10名HH男同病态恋病变（HH是避免男同病态恋不育的少见因可抑制）是否有效。调查报告称克罗米衍生物病患1年后，4名卡尔曼(氏)综合征病变中只有一名病变的胚胎pH增高而全脑垂体特病态与日俱增症病变的胚胎缺乏征状均没有得不到强化。相反，该调查报告反驳3名成年病症的恶病态肿瘤HH男同病态恋病变经过3个月末克罗米衍生物的病患胚胎pH有了明显增高。目当年为止该组病变已有两名完全恢复了生殖。Whitten哈佛大学却说：“除非对克罗米衍生物病患没有反应，我们不会因为征状中止对病变使用该抑制剂。”最后译者回顾却说：“因为条件极少，对HH病变促病态腺激可抑制阿司匹林和克罗米衍生物的随机研究不足以开展，然而利用多续作的严格选择新标准对病变开展分级意味著努力全面实验者克罗米衍生物完全恢复男同病态恋低生殖的有效病态。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编辑：紫色宿命

编辑： 张靖